Can your lube affect your chances of getting pregnant? Yes some lubricants can make it harder for sperm to reach the egg. Look for sperm safe or fertility friendly formulas that mimic your Let's talk about lubricants and fertility. If you're TTC, the type of lube you use can either support or sabotage your chances of conceiving. Here's what research shows: All impact sperm in Is Water Based Lube Sperm Friendly? TTC Lubricant Guide Can we use saliva or any over the counter lubricants when trying to become pregnant???, When youre TTC, regular lubricants can harm sperm movement, so choosing the right one matters.,